Isotretinoin 40 mg, a potent oral medication used for severe acne, typically requires several months to show significant results. Most patients start to see improvements within 4 to 6 weeks of beginning treatment. However, a full course of isotretinoin usually spans 4 to 6 months. The medication works by reducing the size of sebaceous glands, decreasing oil production, and preventing clogged pores, which helps in resolving persistent acne. Initial treatment may cause acne to worsen temporarily as the medication works to purge impurities from the skin, but this usually improves with continued use. Complete resolution of acne can vary among individuals. Some people might experience substantial clearing of acne by the end of the treatment period, while others may need additional courses. Regular follow-ups with a healthcare provider are essential to monitor progress, manage side effects, and determine if further treatment is necessary. Always use isotretinoin under the guidance of a healthcare provider due to its potential side effects and strict monitoring requirements.